United Therapeutics Corporation History
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2024
                                        First successful transplant of a porcine xenothymokidney
                                    
                                     
                                     
                                        
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                                        First successful transplant of a xenokidney from a pig with ten gene edits 500th lung transplant using UT’s EVLP service 
                                    
                                     
                                     
                                        
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                                2023
                                        United Therapeutics and Miromatrix Medical announce completion of tender offer and merger
                                    
                                     
                                     
                                        
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                                        United Therapeutics acquires IVIVA Medical Inc.
                                    
                                     
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2023 Report
                                            
                                            
                                        
                                    2022
                                        First successful xenotransplantation of porcine heart
                                    
                                     
                                     
                                        
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                                        Tyvaso DPI® (treprostinil) inhalation powder approved by the FDA for the treatment of PAH and PH-ILD to improve exercise capacity
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                        
                                        Visit Tyvaso DPI page
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2022 Report
                                            
                                            
                                        
                                    2021
                                        INCREASE results published in New England Journal of Medicine
                                    
                                     
                                     
                                        
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                                        Commercial launch of the Remunity® Pump for Remodulin®
                                    
                                     
                                     
                                        
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                                        FDA approval and launch of Tyvaso® for the treatment of PH-ILD
                                    
                                     
                                     
                                        
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                                        UT becomes a public benefit corporation
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2021 Report
                                            
                                            
                                        
                                    2020
                                        FDA clearance of pharmacy fill Remunity® Pump for Remodulin®
                                    
                                     
                                     
                                        
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                                        Visit Remunity Website
                                        
                                         
                                    
                                
                                        UT issues first Corporate Responsibility Report
                                    
                                     
                                     
                                        
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                                        INCREASE study of Tyvaso® in PH-ILD meets primary endpoint
                                    
                                     
                                     
                                        
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                                        UT launches TETON study in IPF
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2020 Report
                                            
                                            
                                        
                                    2019
                                        UT in-licenses Ralinepag an oral, IP receptor agonist being developed for PAH
                                    
                                     
                                     
                                        
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                                        Orenitram® label expansion and relaunch
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2019 Report
                                            
                                            
                                        
                                    2018
                                        FREEDOM-EV study of Orenitram® meets primary endpoint
                                    
                                     
                                     
                                        
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                                        UT launches collaboration with MannKind for Tyvaso DPI®
                                    
                                     
                                     
                                        
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                                        Health Canada approves Unituxin®
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2018 Report
                                            
                                            
                                        
                                    2017
                                        UT's subsidiary, Lung Biotechnology PBC, launches organ bioprinting program in collaboration with 3D Systems
                                    
                                     
                                     
                                        
                                        Visit Lung Biotechnology Website
                                        
                                         
                                    
                                
                                        FDA approves TD-300 Nebulizer for Tyvaso®
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2017 Report
                                            
                                            
                                        
                                    2016
                                        Launch of Unither 2.0, Major Pipeline Expansion
                                    
                                     
                                     
                                         
                                    
                                
                                        UT obtains $1 billion unsecured line of credit
                                    
                                     
                                     
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2016 Report
                                            
                                            
                                        
                                    2015
                                        Unituxin® approved by FDA to treat high-risk neuroblastoma
                                    
                                     
                                     
                                        
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                                        Visit Unituxin Website
                                        
                                         
                                    
                                
                                        UT enters into collaboration with Mayo Clinic to build and operate an ex-vivo lung perfusion center in Jacksonville, Florida
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2015 Report
                                            
                                            
                                        
                                    2014
                                        Japanese regulators approve Remodulin® for PAH under the brand name Treprost™
                                    
                                     
                                     
                                        
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                                        First ex-vivo lung perfusion procedure performed by Lung Bioengineering, a subsidiary of UT
                                    
                                     
                                     
                                        
                                        Visit Lung Bioengineering website
                                        
                                         
                                    
                                
                                        UT opens Regenerative Medicine Lab in Research Triangle Park, North Carolina, with a focus on manufacturing lungs and lung lobes for transplant
                                    
                                     
                                     
                                         
                                    
                                
                                        UT and DEKA Research & Development Corp. enter into an agreement to develop a next-generation subcutaneous pump for Remodulin®, which ultimately resulted in the Remunity® Pump for Remodulin®
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2014 Report
                                            
                                            
                                        
                                    2013
                                        Orenitram® approved by FDA for the treatment of PAH to improve exercise capacity
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                        
                                        Visit Orenitram Website
                                        
                                         
                                    
                                
                                        UT annual revenues surpass $1 billion
                                    
                                     
                                     
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2013 Report
                                            
                                            
                                        
                                    2011
                                        FREEDOM-M study of Orenitram® meets primary endpoint
                                    
                                     
                                     
                                        
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                                        Intravenous Remodulin® approved in most of E.U.
                                    
                                     
                                     
                                        
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                                        Adcirca® becomes most prescribed drug for PAH
                                    
                                     
                                     
                                         
                                    
                                
                                        United Therapeutics acquires Revivicor xenotransplantation program
                                    
                                     
                                     
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2011 Report
                                            
                                            
                                        
                                    
                                        Annual Report Soundtrack
                                    
                                    
                                    
                                        
                                        01 – “Dear Shareholders” performed by the Alan Scott Band
                                        
                                            
                                        
                                        
                                        02 – “Live it up” performed by the Alan Scott Band
                                        
                                            
                                        
                                        
                                        03 – “2011” performed by the Alan Scott Band
                                        
                                            
                                        
                                        
                                        04 – “Helicopter” performed by the Alan Scott Band
                                        
                                            
                                        
                                        
                                    
                                     
                                    
                                2010
                                        United Therapeutics launches collaboration with National Cancer Institute to develop a monoclonal antibody for treatment of high-risk neuroblastoma, which is today known as Unituxin®
                                    
                                     
                                     
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2010 Report
                                            
                                            
                                        
                                    2009
                                        UT surpasses $1 billion in assets
                                    
                                     
                                     
                                         
                                    
                                
                                        Adcirca® approved by FDA for the treatment of PAH to improve exercise capacity
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                        
                                        Visit Adcirca Website
                                        
                                         
                                    
                                
                                        Tyvaso® approved by FDA for the treatment of PAH to improve exercise capacity
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                        
                                        Visit Tyvaso Website
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2009 Report
                                            
                                            
                                        
                                    2008
                                        UT in-licenses U.S. commercialization rights to Adcirca® for PAH from Eli Lilly and Company
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2008 Report
                                            
                                            
                                        
                                    2007
                                        TRIUMPH-1 study of inhaled treprostinil meets primary endpoint
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2007 Report
                                            
                                            
                                        
                                    2006
                                        FDA approves expansion of Remodulin® label to include transitions from Flolan®
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2006 Report
                                            
                                            
                                        
                                    2005
                                        Remodulin®® approved by 23 countries in the European Union for the treatment of PAH to improve exercise capacity by subcutaneous infusion
                                    
                                     
                                     
                                        
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                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2005 Report
                                            
                                            
                                        
                                    2004
                                        FDA approves expansion of Remodulin® label to include treatment of PAH by intravenous infusion
                                    
                                     
                                     
                                        
                                        Read the Press Release
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2004 Report
                                            
                                            
                                        
                                    2003
                                        UT commences first human clinical trial of an oral formulation of treprostinil
                                    
                                     
                                     
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2003 Report
                                            
                                            
                                        
                                    2002
                                        Remodulin® approved in the United States, Canada and Israel to treat PAH by subcutaneous infusion
                                    
                                     
                                     
                                        
                                        Visit Remodulin Website
                                        
                                         
                                    
                                
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2002 Report
                                            
                                            
                                        
                                    2001
                                            United Therapeutics Corporation Annual Report
                                        
                                        
                                        
                                            
                                            View 2001 Report
                                            
                                            
                                        
                                    2000
                                        UT submits new drug application to FDA for Remodulin® to treat pulmonary arterial hypertension
                                    
                                     
                                     
                                         
                                    
                                1999
                                        United Therapeutics acquires rights to treprostinil from Glaxo Wellcome Inc.
                                    
                                     
                                     
                                         
                                    
                                
                                        United Therapeutics acquires Synquest, Inc., providing in-house capacity and expertise to manufacture treprostinil
                                    
                                     
                                     
                                         
                                    
                                1997
                                        Initial public offering (Nasdaq:UTHR), priced at $12.00 per share
                                    
                                     
                                     
                                         
                                    
                                1996
                                        United Therapeutics founded by Martine Rothblatt to find a cure for her daughter's life- threatening condition, now known as pulmonary arterial hypertension
                                    
                                     
                                     
                                         
                                    
                                 
                                 
                                 
                                 
                                     
                                 
                                 
                                 
                                     
                                 
                                 
                                     
                                 
                                     
                                 
                                 
                                 
                                     
                                 
                                     
                                 
                                     
                                 
                                     
                                 
                                 
                                 
                                     
                                 
                                     
                                     
                                     
                                 
                                 
                                     
                                     
                                     
                                     
                                     
                                     
                                     
                                     
                                    